Tackling cell transplantation anoikis: an injectable, shape memory cryogel microcarrier platform material for stem cell and neuronal cell growth

Newland, Benjamin ORCID: https://orcid.org/0000-0002-5214-2604, Welzel, Petra B., Newland, Heike, Renneberg, Claudia, Kolar, Petr, Tsurkan, Mikhail, Rosser, Anne Elizabeth ORCID: https://orcid.org/0000-0002-4716-4753, Freudenberg, Uwe and Werner, Carsten 2015. Tackling cell transplantation anoikis: an injectable, shape memory cryogel microcarrier platform material for stem cell and neuronal cell growth. Small 11 (38) , pp. 5047-5053. 10.1002/smll.201500898

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Abstract

Highly macroporous semisynthetic cryogel microcarriers can be synthesized for culturing stem cells and neuronal type cells. Growth factors loaded to heparin-containing microcarriers show near zero-order release kinetics and cell-loaded microcarriers can be injected through a fine gauge cannula without negative effect on the cells. These carriers can be applied for cell transplantation applications.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI) Pharmacy
Uncontrolled Keywords:	adherent matrix; biomaterials; heparin; neurotrophin; star-PEG; shape memory; cryogels; microcarriers.
Publisher:	Wiley
ISSN:	1613-6810
Date of First Compliant Deposit:	1 November 2017
Last Modified:	18 Nov 2024 13:30
URI:	https://orca.cardiff.ac.uk/id/eprint/76275

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