Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis

Bourne, C., Aydemir, Ö., Balanzá-Martínez, V., Bora, E., Brissos, S., Cavanagh, J., Clark, L., Cubukcuoglu, Z., Dias, V., Dittmann, S., Ferrier, I., Fleck, D., Frangou, S., Gallagher, P., Jones, L., Kieseppä, T., Martínez-Aran, A., Melle, I., Moore, P., Mur, M., Pfennig, A., Raust, A., Senturk, V., Simonsen, C., Smith, D., Bio, D., Soeiro-de-Souza, M., Stoddart, S., Sundet, K., Szöke, A., Thompson, J., Torrent, C., Zalla, T., Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610, Andreassen, O., Leboyer, M., Vieta, E., Bauer, M., Worhunsky, P., Tzagarakis, C., Rogers, R., Geddes, J. and Goodwin, G. 2013. Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis. Acta Psychiatrica Scandinavica 128 (3) , pp. 149-162. 10.1111/acps.12133

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Abstract

Objective: An association between bipolar disorder and cognitive impairment has repeatedly been described, even for euthymic patients. Findings are inconsistent both across primary studies and previous meta-analyses. This study reanalysed 31 primary data sets as a single large sample (N = 2876) to provide a more definitive view. Method: Individual patient and control data were obtained from original authors for 11 measures from four common neuropsychological tests: California or Rey Verbal Learning Task (VLT), Trail Making Test (TMT), Digit Span and/or Wisconsin Card Sorting Task. Results: Impairments were found for all 11 test-measures in the bipolar group after controlling for age, IQ and gender (Ps ≤ 0.001, E.S. = 0.26-0.63). Residual mood symptoms confound this result but cannot account for the effect sizes found. Impairments also seem unrelated to drug treatment. Some test-measures were weakly correlated with illness severity measures suggesting that some impairments may track illness progression. Conclusion: This reanalysis supports VLT, Digit Span and TMT as robust measures of cognitive impairments in bipolar disorder patients. The heterogeneity of some test results explains previous differences in meta-analyses. Better controlling for confounds suggests deficits may be smaller than previously reported but should be tracked longitudinally across illness progression and treatment.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RZ Other systems of medicine
Uncontrolled Keywords:	Adult; Affect; Affective Symptoms; Age of Onset; Bipolar Disorder; Cognition Disorders; Confounding Factors (Epidemiology); Female; Humans; Male; Mental Competency; Mental Processes; Middle Aged; Neuropsychological Tests; Psychiatric Status Rating Scales; Psychotropic Drugs; Risk Factors
Publisher:	Wiley-Blackwell
ISSN:	0001-690X
Last Modified:	28 Oct 2022 10:02
URI:	https://orca.cardiff.ac.uk/id/eprint/76486

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