Investigation of phthalate release from tracheal tubes

Morton, W., Muller, Carsten Theodor ORCID: https://orcid.org/0000-0003-0455-7132, Goodwin, Naomi, Wilkes, A and Hall, Judith Elizabeth ORCID: https://orcid.org/0000-0002-6770-7372 2013. Investigation of phthalate release from tracheal tubes. Anaesthesia 68 (4) , pp. 377-381. 10.1111/anae.12083

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Abstract

Phthalates are chemicals used extensively in the manufacture of plastics for their desirable physical characteristics. In addition to enhancing the performance of plastics, phthalates have a number of undesirable effects, principally endocrine disruptor effects, that may have adverse effects on reproductive development and functioning. As a result, they have been banned from the manufacture of children's toys. Despite this, they continue to be used in the manufacture of medical devices, including anaesthetic equipment. This study aimed to assess phthalate release from five brands of tracheal tube. Using gas chromatography-mass spectrometry, we analysed phthalate concentrations from samples of ultra pure water in which tracheal tubes had been submerged. Phthalate concentration increased from 6.7 to 149 μg.l-1 over a period of 4.8 days. Phthalate release from anaesthetic equipment has not previously been documented over short time periods and raises the possibility of iatrogenic endocrine disruption with routine anaesthesia.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine R Medicine > RZ Other systems of medicine
Uncontrolled Keywords:	Anesthesiology; Diethylhexyl Phthalate; Equipment Design; Gas Chromatography-Mass Spectrometry; Intubation, Intratracheal; Phthalic Acids; Plasticizers; Plastics; Water
Publisher:	Wiley-Blackwell
ISSN:	0003-2409
Last Modified:	23 May 2024 01:13
URI:	https://orca.cardiff.ac.uk/id/eprint/76528

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