Integrating next-generation sequencing into the diagnostic testing of inherited cancer predisposition

Ku, C., Cooper, David Neil ORCID: https://orcid.org/0000-0002-8943-8484, Iacopetta, B. and Roukos, D. 2013. Integrating next-generation sequencing into the diagnostic testing of inherited cancer predisposition. Clinical Genetics 83 (1) , pp. 2-6. 10.1111/cge.12028

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Abstract

The clinical application of next-generation sequencing (NGS) as a diagnostic tool has become increasingly evident. The coupling of NGS technologies with new genomic sequence enrichment methods has made the sequencing of panels of target genes technically feasible, at the same time as making such an approach cost-effective for diagnostic applications. In this article, we discuss recent studies that have applied NGS in the diagnostic setting in relation to hereditary cancer.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Uncontrolled Keywords:	Genetic Predisposition to Disease; Genome, Human; High-Throughput Nucleotide Sequencing; Humans; Molecular Diagnostic Techniques; Neoplasms
Publisher:	Wiley-Blackwell
ISSN:	0009-9163
Last Modified:	28 Oct 2022 10:04
URI:	https://orca.cardiff.ac.uk/id/eprint/76617

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