Dissociable brain correlates for depression, anxiety, dissociation, and somatization in depersonalization-derealization disorder

Lemche, Erwin, Surguladze, Simon A., Brammer, Michael J., Phillips, Mary L., Sierra, Mauricio, David, Anthony S., Williams, Steven C. R. and Giampietro, Vincent P. 2013. Dissociable brain correlates for depression, anxiety, dissociation, and somatization in depersonalization-derealization disorder. CNS Spectrums , p. 1. 10.1017/S1092852913000588

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Abstract

Abstract Objective: The cerebral mechanisms of traits associated with depersonalization-derealization disorder (DPRD) remain poorly understood. Method: Happy and sad emotion expressions were presented to DPRD and non-referred control (NC) subjects in an implicit event-related functional magnetic resonance imaging (fMRI) design, and correlated with self report scales reflecting typical co-morbidities of DPRD: depression, dissociation, anxiety, somatization. Results: Significant differences between the slopes of the two groups were observed for somatization in the right temporal operculum (happy) and ventral striatum, bilaterally (sad). Discriminative regions for symptoms of depression were the right pulvinar (happy) and left amygdala (sad). For dissociation, discriminative regions were the left mesial inferior temporal gyrus (happy) and left supramarginal gyrus (sad). For state anxiety, discriminative regions were the left inferior frontal gyrus (happy) and parahippocampal gyrus (sad). For trait anxiety, discriminative regions were the right caudate head (happy) and left superior temporal gyrus (sad). Discussion: The ascertained brain regions are in line with previous findings for the respective traits. The findings suggest separate brain systems for each trait.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Schools > Medicine
Subjects:	R Medicine > R Medicine (General)
ISSN:	1092-8529
Last Modified:	14 Sep 2015 10:38
URI:	https://orca.cardiff.ac.uk/id/eprint/76691

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