Plasmid carriage of blaNDM-1 in clinical Acinetobacter baumannii isolates from India

Jones, Lim S., Toleman, Mark A. ORCID: https://orcid.org/0000-0002-9497-0512, Weeks, Janis L., Howe, Robin A., Walsh, Timothy R. ORCID: https://orcid.org/0000-0003-4315-4096 and Kumarasamy, Karthikeyan K. 2014. Plasmid carriage of blaNDM-1 in clinical Acinetobacter baumannii isolates from India. Antimicrobial Agents and Chemotherapy 58 (7) , pp. 4211-4213. 10.1128/AAC.02500-14

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Abstract

NDM-1 probably emerged in Acinetobacter species prior to its dissemination among Enterobacteriaceae, and NDM-1-like enzymes are increasingly reported in Acinetobacter species. Here, we report on the genetic context of blaNDM-1 in the earliest known NDM-1-producing organisms, clinical isolates of Acinetobacter from India in 2005. These strains harbor blaNDM-1 plasmids of different sizes. The gene is associated with the remnants of the Tn125 transposon normally associated with blaNDM-1 in Acinetobacter spp. The transposon has been disrupted by the IS26 insertion and subsequent movement events.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > QR Microbiology
Publisher:	American Society for Microbiology
ISSN:	0066-4804
Date of Acceptance:	13 April 2014
Last Modified:	28 Oct 2022 10:28
URI:	https://orca.cardiff.ac.uk/id/eprint/78421

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