Kashir, Junaid, Nomikos, Michail, Lai, Francis  ORCID: https://orcid.org/0000-0003-2852-8547 and Swann, Karl ORCID: https://orcid.org/0000-0002-4355-1449
2014.
Sperm-induced Ca2+ release during egg activation in mammals.
Biochemical and Biophysical Research Communications
450
(3)
, pp. 1204-1211.
10.1016/j.bbrc.2014.04.078
|
Abstract
This review discusses the role that the sperm-specific phospholipase C zeta (PLCζ) is proposed to play during the fertilization of mammalian eggs. At fertilization, the sperm initiates development by causing a series of oscillations in cytosolic concentrations of calcium [Ca2] within the egg. PLCζ mimics the sperm at fertilization, causing the same pattern of Ca2+ release as seen at fertilization. Introducing PLCζ into mouse eggs also mimics a number of other features of the way in which the fertilizing sperm triggers Ca2+ oscillations. We discuss the localization of PLCζ within the egg and present a hypothesis about the localization of PLCζ within the sperm before the initiation of fertilization.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Biosciences Schools > Medicine |
| Subjects: | R Medicine > RG Gynecology and obstetrics |
| Publisher: | Elsevier |
| ISSN: | 0006-291X |
| Date of Acceptance: | 7 April 2014 |
| Last Modified: | 16 Nov 2022 23:34 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/78512 |
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