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Sperm-induced Ca2+ release during egg activation in mammals

Kashir, Junaid, Nomikos, Michail, Lai, Francis and Swann, Karl 2014. Sperm-induced Ca2+ release during egg activation in mammals. Biochemical and Biophysical Research Communications 450 (3) , pp. 1204-1211. 10.1016/j.bbrc.2014.04.078

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This review discusses the role that the sperm-specific phospholipase C zeta (PLCζ) is proposed to play during the fertilization of mammalian eggs. At fertilization, the sperm initiates development by causing a series of oscillations in cytosolic concentrations of calcium [Ca2] within the egg. PLCζ mimics the sperm at fertilization, causing the same pattern of Ca2+ release as seen at fertilization. Introducing PLCζ into mouse eggs also mimics a number of other features of the way in which the fertilizing sperm triggers Ca2+ oscillations. We discuss the localization of PLCζ within the egg and present a hypothesis about the localization of PLCζ within the sperm before the initiation of fertilization.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: R Medicine > RG Gynecology and obstetrics
Publisher: Elsevier
ISSN: 0006-291X
Date of Acceptance: 7 April 2014
Last Modified: 17 May 2022 09:19

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