The role of tight junctions in cancer metastasis

Martin, Tracey Amanda ORCID: https://orcid.org/0000-0003-2690-4908 2014. The role of tight junctions in cancer metastasis. Seminars in Cell and Developmental Biology 36 , pp. 224-231. 10.1016/j.semcdb.2014.09.008

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Abstract

Over the last decade, it has become apparent that the tight junction (TJ) is a key component in tumour progression and metastasis. In addition to its role in the control of paracellular diffusion of ions and certain molecules, the TJ has a vital role in maintaining cell to cell adhesion and tissue integrity. Changes in the expression and/or distribution of TJ proteins can result in loss in cohesion of the TJ structure, which in turn results in the ability of cancer cells to become invasive and then ultimately lead to the metastasis of cancer cells. This review will discuss recent insights into how TJ are involved in the process of tumour metastasis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	Tight junction; Tumour; Metastasis
Publisher:	Elsevier
ISSN:	1084-9521
Last Modified:	28 Oct 2022 10:29
URI:	https://orca.cardiff.ac.uk/id/eprint/78526

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