Taylor, Peter N.  ORCID: https://orcid.org/0000-0002-3436-422X, Okosieme, Onyebuchi E., Murphy, Rhian, Hales, Charlotte ORCID: https://orcid.org/0000-0001-8638-6626, Chiusano, Elisabetta, Maina, Aldo, Joomun, Mohamed, Bestwick, Jonathan P., Smyth, Peter, Paradice, Ruth, Channon, Sue, Braverman, Lewis E., Dayan, Colin M. ORCID: https://orcid.org/0000-0002-6557-3462, Lazarus, John H. and Pearce, Elizabeth N.
2014.
Maternal perchlorate levels in women with borderline thyroid function during pregnancy and the cognitive development of their offspring: data from the controlled antenatal thyroid study.
Journal of Clinical Endocrinology and Metabolism
99
(11)
, pp. 4291-4298.
10.1210/jc.2014-1901
|
Abstract
Objective: Thyroid dysfunction is associated with impaired cognitive development. Perchlorate decreases thyroidal iodine uptake, potentially reducing thyroid hormone production. It is unclear whether perchlorate exposure in early life affects neurodevelopment. Design: Historical cohort analysis. Patients: From 2002 to 2006, 21,846 women at gestational age <16 weeks recruited from antenatal clinics in Cardiff, UK and Turin, Italy were enrolled in the Controlled Antenatal Thyroid Screening Study (CATS). We undertook a retrospective analysis of 487 mother-child pairs in mothers who were hypothyroid/hypothyroxinemic during pregnancy and analyzed whether first trimester maternal perchlorate levels in the highest 10% of the study population were associated with increased odds of offspring IQ being in the lowest 10% at 3 years of age. Main Outcome Measures: Maternal urinary perchlorate, offspring IQ. Results: Urine perchlorate was detectable in all women (median 2.58 μg/L); iodine levels were low (median 72 μg/L). Maternal perchlorate levels in the highest 10% of the population increased the odds of offspring IQ being in the lowest 10% OR = 3.14 (95% CI 1.38, 7.13) P = .006 with a greater negative impact observed on verbal OR = 3.14 (95% CI 1.42, 6.90) P = .005 than performance IQ. Maternal levothyroxine therapy did not reduce the negative impact of perchlorate on offspring IQ. Conclusions: This is the first study using individual-level patient data to study maternal perchlorate exposure and offspring neurodevelopment and suggests that high-end maternal perchlorate levels in hypothyroid/hypothyroxinemic pregnant women have an adverse effect on offspring cognitive development, not affected by maternal levothyroxine therapy. These results require replication in additional studies, including in the euthyroid population.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI) |
| Subjects: | R Medicine > R Medicine (General) |
| Publisher: | Oxford University Press |
| ISSN: | 0021-972X |
| Date of Acceptance: | 16 July 2014 |
| Last Modified: | 28 Oct 2022 10:31 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/78663 |
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