Re(VII) and Tc(VII) trioxo complexes stabilized by tridentate ligands and their potential use as radiopharmaceuticals

Hahn, Eva M., Casini, Angela ORCID: https://orcid.org/0000-0003-1599-9542 and Kuehn, Fritz E. 2014. Re(VII) and Tc(VII) trioxo complexes stabilized by tridentate ligands and their potential use as radiopharmaceuticals. Coordination Chemistry Reviews 276 , pp. 97-111. 10.1016/j.ccr.2014.05.021

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Abstract

Tc(VII) and Re(VII) trioxo complexes are currently arousing interest because of their potential use as radiopharmaceuticals due to their hydrophilic character and stability in a biological environment. The radioactive isotopes 99mTc and 188Re are readily obtained from commercially available 99Mo/99mTc or 188W/188Re generators, respectively. Stabilization of the [MO3]+ species is achieved by coordination of tridentate ligands (N, O, S and Pt donors). Herein, the various synthetic strategies to synthesize these complexes starting from M2O7, [MO4]−, M(+V), M(+III) or M(+I) species are revised. The main structural features of the obtained distorted octahedral metal compounds are presented on the basis of their characterization by NMR and IR spectroscopy, and X-ray crystallography. Interestingly, the [MO3]+ complexes undergo cycloaddition reactions, either to form the corresponding M(+V) diolate complexes via [3 + 2] cycloaddition, or carbene complexes via [2 + 2] cycloaddition. In this review we also comment on the few reported examples using [3 + 2] cycloaddition to label the trioxo compounds with bioactive molecules for their potential application as radiopharmaceuticals.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	Elsevier
Date of Acceptance:	22 May 2014
Last Modified:	31 Oct 2022 08:56
URI:	https://orca.cardiff.ac.uk/id/eprint/79298

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