Conjugation of organoruthenium(II) 3-(1H-Benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and indolo[3,2-d]benzazepines to recombinant human serum albumin: a strategy to enhance Cytotoxicity in Cancer Cells

Stepanenko, Iryna N., Casini, Angela ORCID: https://orcid.org/0000-0003-1599-9542, Edafe, Fabio, Novak, Maria S., Arion, Vladimir B., Dyson, Paul J., Jakupec, Michael A. and Keppler, Bernhard K. 2011. Conjugation of organoruthenium(II) 3-(1H-Benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and indolo[3,2-d]benzazepines to recombinant human serum albumin: a strategy to enhance Cytotoxicity in Cancer Cells. Inorganic Chemistry 50 (24) , pp. 12669-12679. 10.1021/ic201801e

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Abstract

Five organoruthenium complexes [RuCl(η6-arene)(L)]Cl with a modified arene ligand, namely, 4-formylphenoxyacetyl-η6-benzylamide, and L = 3-(1H-benzimidazol-2-yl)-1H-pyrazolo[3,4-b]pyridines or indolo[3,2-d]benzazepines were synthesized and conjugated to recombinant human serum albumin in order to improve their drug targeting and delivery to cancer cells, and a marked increase in cytotoxicity was observed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Chemistry
Subjects:	Q Science > QD Chemistry R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher:	American Chemical Society
Last Modified:	31 Oct 2022 08:57
URI:	https://orca.cardiff.ac.uk/id/eprint/79325

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