The x-ray structure of the adduct between NAMI-A and carbonic anhydrase provides insights into the reactivity of this metallodrug with proteins

Casini, Angela ORCID: https://orcid.org/0000-0003-1599-9542, Temperini, Claudia, Gabbiani, Chiara, Supuran, Claudiu T. and Messori, Luigi 2010. The x-ray structure of the adduct between NAMI-A and carbonic anhydrase provides insights into the reactivity of this metallodrug with proteins. ChemMedChem 5 (12) , pp. 1989-1994. 10.1002/cmdc.201000331

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Abstract

Heavy metals rock! The reactivity of the antimetastatic metallodrug NAMI-A with human carbonic anhydrase II (hCAII) has been investigated using a number of techniques, including X-ray crystallography. The characterization of the interactions between NAMI-A and hCAII provides valuable information on the molecular mechanisms responsible for the activity of this promising anticancer agent.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	Wiley-Blackwell
ISSN:	1860-7179
Last Modified:	31 Oct 2022 08:57
URI:	https://orca.cardiff.ac.uk/id/eprint/79336

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