Cytotoxic profile and peculiar reactivity with biomolecules of a novel "rule-breaker" iodidoplatinum(II) complex

Messori, Luigi, Casini, Angela ORCID: https://orcid.org/0000-0003-1599-9542, Gabbiani, Chiara, Michelucci, Elena, Cubo, Leticia, Rios-Luci, Carla, Padron, Jose M., Navarro-Ranninger, Carmen and Quiroga, Adoracion G. 2010. Cytotoxic profile and peculiar reactivity with biomolecules of a novel "rule-breaker" iodidoplatinum(II) complex. ACS Medicinal Chemistry Letters 1 (8) , pp. 381-385. 10.1021/ml100081e

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Abstract

Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably, this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	American Chemical Society
Last Modified:	31 Oct 2022 08:57
URI:	https://orca.cardiff.ac.uk/id/eprint/79337

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