ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme

Casini, Angela ORCID: https://orcid.org/0000-0003-1599-9542, Mastrobuoni, Guido, Temperini, Claudia, Gabbiani, Chiara, Francese, Simona, Moneti, Gloriano, Supuran, Claudiu T., Scozzafava, Andrea and Messori, Luigi 2007. ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme. Chemical Communications (2) , pp. 156-158. 10.1039/B611122J

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Abstract

The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug–protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 Å resolution, reveals selective platination of imidazole Nε of His15.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Chemistry
Subjects:	Q Science > QD Chemistry R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher:	Royal Society of Chemistry
ISSN:	1359-7345
Date of Acceptance:	11 October 2006
Last Modified:	31 Oct 2022 08:59
URI:	https://orca.cardiff.ac.uk/id/eprint/79378

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