Implementing GRADE: calculating the risk difference from the baseline risk and the relative risk

Newcombe, Robert ORCID: https://orcid.org/0000-0003-4400-8867 and Bender, Ralf 2014. Implementing GRADE: calculating the risk difference from the baseline risk and the relative risk. Evidence-Based Medicine 19 (1) , pp. 6-8. 10.1136/eb-2013-101340

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Abstract

A key step in implementing the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system is the estimation of a risk difference based on estimates of the baseline risk and the relative risk estimated from different sources. In this paper we describe a simple and effective method to calculate confidence intervals (CIs) for the risk difference for this situation. Whenever an independent source is available to estimate the baseline risk for the population to which the effect estimates should be applied, this source should be used and CIs for the absolute risk difference should be calculated taking all sources of uncertainty into account.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	British Medical Journal Publishing Group
ISSN:	1356-5524
Last Modified:	31 Oct 2022 09:01
URI:	https://orca.cardiff.ac.uk/id/eprint/79507

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