Nutrition economic evaluation of a probiotic in the prevention of antibiotic-associated diarrhea

Lenoir-Wijnkoop, Irene, Nuijten, Mark J.C., Craig, Joyce and Butler, Christopher ORCID: https://orcid.org/0000-0002-0102-3453 2014. Nutrition economic evaluation of a probiotic in the prevention of antibiotic-associated diarrhea. Frontiers in Pharmacology 5 , 13. 10.3389/fphar.2014.00013

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Abstract

Introduction: Antibiotic-associated diarrhea (AAD) is common and frequently more severe in hospitalized elderly adults. It can lead to increased use of healthcare resources. We estimated the cost-effectiveness of a fermented milk (FM) with probiotic in preventing AAD and in particular Clostridium difficile-associated diarrhea (CDAD). Methods: Clinical effectiveness data and cost information were incorporated in a model to estimate the cost impact of administering a FM containing the probiotic Lactobacillus paracasei ssp paracasei CNCM I-1518 in a hospital setting. Preventing AAD by the consumption of the probiotic was compared to no preventive strategy. Results: The probiotic intervention to prevent AAD generated estimated mean cost savings of £339 per hospitalized patient over the age of 65 years and treated with antibiotics, compared to no preventive probiotic. Estimated cost savings were sensitive to variation in the incidence of AAD, and to the proportion of patients who develop non-severe/severe AAD. However, probiotics remained cost saving in all sensitivity analyses. Conclusion: Use of the fermented dairy drink containing the probiotic L. paracasei CNCM I-1518 to prevent AAD in older hospitalized patients treated with antibiotics could lead to substantial cost savings.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General)
Additional Information:	Copyright © 2014 Lenoir-Wijnkoop, Nuijten, Craig and Butler. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Publisher:	Frontiers
ISSN:	1663-9812
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	23 January 2014
Last Modified:	05 May 2023 13:21
URI:	https://orca.cardiff.ac.uk/id/eprint/79565

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