8OHdG as a marker for Huntington disease progression

Long, Jeffrey D., Matson, Wayne R., Juhl, Andrew R., Leavitt, Blair R., Paulsen, Jane S., Price, Kathleen and Rosser, Anne Elizabeth ORCID: https://orcid.org/0000-0002-4716-4753 2012. 8OHdG as a marker for Huntington disease progression. Neurobiology of Disease 46 (3) , pp. 625-634. 10.1016/j.nbd.2012.02.012

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Abstract

Leukocyte 8-hydroxydeoxyguanosine (8OHdG) is an indicator of oxidative stress, impaired metabolism, and mitochondrial dysfunction, features that have been implicated in Huntington disease (HD). Increased levels of 8OHdG have been reported in the caudate, parietal cortex, and peripherally in the serum and leukocytes, in patients diagnosed with HD. However, little is known about levels in prodromal patients and changes that might occur as the disease progresses. To address these issues, 8OHdG was tracked over time for a subset of participants enrolled in the PREDICT-HD study. Participants were stratified into four groups based on proximity to HD diagnosis at study entry: Controls (gene-negative individuals), Low (low probability of near-future diagnosis), Medium, and High. Blood samples were analyzed using Liquid Chromatography Electrochemical Array, and for comparison purposes, a separate cross-sectional sample was analyzed using liquid chromatography coupled with multiple-reaction-monitoring mass spectrometry. Longitudinal data analysis showed that initial status (at study entry) and annual rate of change varied as a function of proximity group, adjusting for sex, education, age at study entry, and site effects. Overall levels were lowest for the Control group and highest for the High group, and the rate of increase varied in a similar manner. The finding that 8OHdG concentrations increased as a function of proximity to projected disease diagnosis and duration indicates support for the continued assessment of 8OHdG as a robust clinical HD biomarker.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Additional Information:	Kathleen Price and Anne Rosser are collaborators on this article.
Publisher:	Elsevier
ISSN:	0969-9961
Last Modified:	31 Oct 2022 09:07
URI:	https://orca.cardiff.ac.uk/id/eprint/79886

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