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Rapid innate control of antigen abrogates adaptive immunity

Pembroke, Thomas, Gallimore, Awen ORCID: and Godkin, Andrew ORCID: 2013. Rapid innate control of antigen abrogates adaptive immunity. Immunology 138 (4) , pp. 293-297. 10.1111/imm.12048

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Natural killer (NK) cells provide an immediate first line of defence against viral infections. Memory responses, maintained by CD4+ T cells, require exposure to viral antigen and provide long-term protection against future infections. It is known that NK cells can promote the development of the adaptive response through cytokine production and cross-talk with antigen-presenting cells. In this paper however, we summarize a series of recent publications, in mouse models and for the first time in man, with the unifying message that rapid viral antigen control by the innate immune system limits antigen exposure to CD4+ cells thereby abrogating the development of a memory response. We discuss the significant implication of these studies on viral treatment strategies and immunization models.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > R Medicine (General)
Uncontrolled Keywords: Adaptive Immunity; Animals; Antigens, Viral; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytokines; Dendritic Cells; Humans; Immunity, Innate; Immunologic Memory; Killer Cells, Natural; Mice; Models, Immunological; Virus Diseases; Viruses
Publisher: Wiley Blackwell
ISSN: 0019-2805
Date of Acceptance: 26 November 2012
Last Modified: 31 Oct 2022 09:11

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