Neural systems of threat processing in adolescents: Role of pubertal maturation and relation to measures of negative affect

Forbes, Erika E., Phillips, Mary L., Silk, Jennifer S., Ryan, Neal D. and Dahl, Ronald E. 2011. Neural systems of threat processing in adolescents: Role of pubertal maturation and relation to measures of negative affect. Developmental Neuropsychology 36 (4) , pp. 429-452. 10.1080/87565641.2010.550178

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Abstract

Adolescence ushers in dramatic social and affective changes and increased vulnerability for affective disorders. Yet, little is known about the effects of pubertal maturation on neural systems of social threat processing. We examined adolescents' brain function to social stimuli in relation to pubertal maturation, depressive symptoms, and real-world subjective negative affect. Compared with pre/early adolescents, mid/late adolescents exhibited less amygdala reactivity to emotionally neutral faces relative to non-face stimuli; less ventrolateral prefrontal cortex (VLPFC) reactivity to fearful faces relative to non-face stimuli, neutral faces, or angry faces; and more VLPFC reactivity to angry relative to neutral faces. Amygdala and VLPFC reactivity were correlated with negative affect and depressive symptoms. Threat-processing changes during puberty may facilitate changes in social behavior and negative affect.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Schools > Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Psychology Press
ISSN:	8756-5641
Last Modified:	04 Nov 2015 10:46
URI:	https://orca.cardiff.ac.uk/id/eprint/80458

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