Relationship between homozygosity at the dopamine D3 receptor gene and schizophrenia

Mant, R., Williams, J., Asherson, P., Parfitt, E., McGuffin, P. and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 1994. Relationship between homozygosity at the dopamine D3 receptor gene and schizophrenia. American Journal of Medical Genetics 54 (1) , pp. 21-26. 10.1002/ajmg.1320540106

Full text not available from this repository.

Abstract

We have reported an association between schizophrenia and homozygosity of a Bal I polymorphism in the first exon of the dopamine D3 receptor gene (Crocq et al.: Journal of Medical Genetics 29:858–860, 1992). The present study consists of an attempt to replicate this finding in a further sample of 66 patients and 97 controls. Once again more patients than controls were homozygous, but the effect was not as strong as in our first study (χ2 = 2.53, P = 0.05, one tailed). When pooled data from our two studies were analysed, excess homozygosity in patients remained highly significant (P = 0.002) with a particular excess of the 1 : 1 genotype (P = 0.01). This reflected a departure from Hardy-Weinberg equilibrium in the patients (P = 0.0005) but not the controls (P = 0.24). This led us to explore the possibility that there might be important differences between the patients in our two studies and that excess homozygosity might be a characteristic of particular subgroups of schizophrenics. Our findings suggest that the effect is consistently at its strongest in those patients who have a high familial loading and in those who have a good response to neuroleptic treatment, and that differences between our two samples might have contributed to the quantitatively different outcomes

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Wiley
ISSN:	0148-7299
Last Modified:	31 Oct 2022 09:20
URI:	https://orca.cardiff.ac.uk/id/eprint/80625

Citation Data

Cited 112 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item