Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.

Crocq, M A, Mant, R, Asherson, P, Williams, Julie ORCID: https://orcid.org/0000-0002-4069-0259, Hode, Y, Mayerova, A, Collier, D, Lannfelt, L, Sokoloff, P and Schwartz, J C 1992. Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. Journal of Medical Genetics 29 (12) , pp. 858-860. 10.1136/jmg.29.12.858

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Abstract

Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Journal of medical genetics
ISSN:	1468-6244
Last Modified:	31 Oct 2022 09:23
URI:	https://orca.cardiff.ac.uk/id/eprint/80852

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