No association between apolipoprotein E polymorphisms and general cognitive ability in children

Turic, D., Fisher, P. J., Plomin, R. and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 2001. No association between apolipoprotein E polymorphisms and general cognitive ability in children. Neuroscience Letters 299 (1-2) , pp. 97-100. 10.1016/S0304-3940(00)01789-4

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Abstract

In this work we explored the hypothesis that variation in the gene encoding apolipoprotein E (ApoE) is a factor modifying general cognitive ability (g). A case control sample of 101 high g and 101 average g children was scored for ApoE genotypes and two variants in the transcriptional regulatory region of the gene (Th1/E47cs and -491 AT). No evidence of association between these polymorphisms and g was found. We conclude that variation at these loci is not a factor with a measurable impact on general cognitive ability in the healthy population.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Limerick : Elsevier Scientific Publishers Ireland
ISSN:	0304-3940
Last Modified:	31 Oct 2022 09:24
URI:	https://orca.cardiff.ac.uk/id/eprint/80899

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