Molecular genetic approaches to puerperal psychosis

Jones, Ian Richard ORCID: https://orcid.org/0000-0001-5821-5889, Lendon, C., Coyle, N., Robertson, E., Brockington, I. and Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610 2001. Molecular genetic approaches to puerperal psychosis. Progress in Brain Research, Vol. 133. Elsevier, pp. 321-331. (10.1016/S0079-6123(01)33024-8)

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Abstract

Puerperal psychosis, an episode of mania or psychosis precipitated by childbirth follows approximately one in 1000 deliveries. The evidence of clinical, outcome and genetic studies supports the hypothesis that the majority of puerperal psychotic episodes are manifestations of an affective disorder diathesis with a puerperal trigger. Furthermore the available evidence supports the hypothesis that genes are involved in susceptibility to both diathesis and trigger. For complex genetic disorders such as affective illness there are marked benefits in focussing on a homogeneous subtype which allows a subset of hypotheses to be tested. Molecular genetic studies of puerperal psychosis provide an excellent example of this strategy, allowing a hierarchy of hypotheses concerning the involvement of neurosteroid pathways in pathophysiology to be tested. Puerperal psychosis results in considerable suffering to a woman and her family. Elucidating the pathophysiological basis of this disorder will lead to better prevention and treatment and, it is anticipated, inform research on affective disorders more generally.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Elsevier
ISSN:	0079-6123
Last Modified:	31 Oct 2022 09:24
URI:	https://orca.cardiff.ac.uk/id/eprint/80914

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