Multiple system atrophy/progressive supranuclear palsy: alpha-Synuclein, synphilin, tau, and APOE

Morris, Huw, Vaughan, J. R., Datta, S. R., Bandopadhyay, R., Rohan De Silva, H. A., Schrag, A., Cairns, N. J., Burn, D., Nath, U., Lantos, P. L., Daniel, S., Lees, A. J., Quinn, N. P. and Wood, N. W. 2000. Multiple system atrophy/progressive supranuclear palsy: alpha-Synuclein, synphilin, tau, and APOE. Neurology 55 (12) , pp. 1918-1920. 10.1212/WNL.55.12.1918

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Abstract

Article abstract-Alpha synuclein, tau, synphilin, and APOE genotypes were analyzed in patients with multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) and controls. The predisposing effect of the tau insertion polymorphism to the development of PSP is confirmed. However, no effect of alpha-synuclein, synphilin, or APOE variability on the development of PSP, or of tau, alpha-synuclein, APOE, or synphilin gene variability on the development of MSA, are demonstrated.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Hagerstown, MD : Lippincott Williams & Wilkins
ISSN:	0028-3878
Last Modified:	26 Nov 2015 11:39
URI:	https://orca.cardiff.ac.uk/id/eprint/80949

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