Pinpointing key mechanisms in Alzheimer's disease development [Commentary]

Williams, Julie ORCID: https://orcid.org/0000-0002-4069-0259 2010. Pinpointing key mechanisms in Alzheimer's disease development [Commentary]. Alzheimer's Research & Therapy 2 (2) , p. 4. 10.1186/alzrt27

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Abstract

van Exel and colleagues present an elegant study testing relationships between vascular and inflammatory traits and the risk of Alzheimer's disease (AD) development. They compared middle-aged offspring of AD cases with similar offspring of nondemented parents and observed greater inflammatory response to challenge and increased hypertension in those at high genetic risk. These observations join a growing body of evidence implicating inflammation/innate immunity as a crucial component in disease development. Recent discoveries of new risk genes for Alzheimer's disease also implicate innate immunity and to some extent vascular health as potentially important in pathogenesis. Further identification and refinement of putative disease mechanisms is likely as the genetic architecture of AD is uncovered through current large-scale association and sequencing studies.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	BioMed Central
ISSN:	1758-9193
Last Modified:	31 Oct 2022 09:27
URI:	https://orca.cardiff.ac.uk/id/eprint/81073

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