Differentiation of atypical parkinsonian syndromes with routine MRI

Schrag, A., Good, C. D., Miszkiel, K., Morris, Huw, Mathias, C. J., Lees, A. J. and Quinn, N. P. 2000. Differentiation of atypical parkinsonian syndromes with routine MRI. Neurology 54 (3) , pp. 697-702. 10.1212/WNL.54.3.697

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Abstract

OBJECTIVE: To evaluate the use of routine MRI in differentiating between patients with progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal degeneration (CBD) and control subjects. METHODS: Two neuroradiologists rated blindly and independently axial T2-weighted and proton density MR images of 54 patients with MSA, 35 patients with PSP, 5 patients with CBD, and 44 control subjects. RESULTS: More than 70% of patients with PSP and more than 80% of patients with cerebellar predominant MSA could be classified correctly with 0.5-T or 1.5-T scans, and no patient in these groups was misclassified. In the remaining patients an unequivocal differentiation could not be made. However, only approximately 50% of patients with parkinsonism-predominant MSA could be classified correctly, and 19% of them (all of whom had had 0.5-T scans) were misclassified. CONCLUSIONS: Characteristic findings on routine MRI, either 1.5 T or 0.5 T, can contribute to the identification of MSA and PSP. However, in a minority of patients no unequivocal diagnosis can be made using MRI findings alone.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Lippincott Williams & Wilkins
ISSN:	0028-3878
Last Modified:	26 Nov 2015 14:03
URI:	https://orca.cardiff.ac.uk/id/eprint/81173

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