Peripheral adrenoceptors and serotonin receptors in depression

Healy, David, Carney, P.A., O'Halloran, A. and Leonard, B.E. 1985. Peripheral adrenoceptors and serotonin receptors in depression. Journal of affective disorders 9 (3) , pp. 285-296. 10.1016/0165-0327(85)90059-X

Full text not available from this repository.

Abstract

Changes in platelet and lymphocyte adrenoceptor densities, platelet serotonin uptake and aggregatory response to serotonin were assessed in a group of moderately depressed patients before and during treatment with either trazodone or amitriptyline. Platelet serotonin receptor activity and uptake were lower before the start of treatment in all patients than in those patients responding to treatment. The densities of alpha 2- and beta-adrenoceptors tended to be higher in the patients before treatment and returned to control values after effective therapy. There were no major differences in the biochemical changes between the patients treated with trazodone or amitriptyline. When the biochemical data was correlated with the clinical history of the patients, it was found that only endogenously depressed patients, and not those with non-endogenous depression, had a significantly reduced platelet serotonin uptake rate. In addition, female depressives had a slightly lower platelet 5-HT aggregatory response than males irrespective to the type of depression.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Schools > Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Elsevier
ISSN:	0165-0327
Last Modified:	03 Dec 2015 12:05
URI:	https://orca.cardiff.ac.uk/id/eprint/81277

Citation Data

Cited 75 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item