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Autosome search for schizophrenia susceptibility genes in multiply affected families

Rees, M. I., Fenton, I., Williams, Nigel Melville ORCID:, Holmans, Peter Alan ORCID:, Norton, N., Cardno, A., Asherson, P., Spurlock, G., Vallada, H., Dawson, E., Li, M. W., Collier, D. A., Powell, J. F., Nanko, S., Gill, M., McGuffin, P. and Owen, Michael John ORCID: 1999. Autosome search for schizophrenia susceptibility genes in multiply affected families. Molecular Psychiatry 4 (4) , pp. 353-359. 10.1038/

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We have analysed 298 polymorphic markers in 13 families multiply affected with schizophrenia and related disorders using a combination of radiolabelled and fluorescent-based methodologies. The markers were distributed throughout the autosomes at an average spacing of 12.8 cM. The data were analysed with two-point linkage analysis (MLINK) and heterogeneity testing (HOMOG). Several genetic models were used ranging from near dominant to fully recessive. Multi-point analysis was performed for 27 regions demonstrating either contiguously positive lod scores in two or more consecutive markers, and in regions with two-point lod score(s) of 1.0 or above in a single marker. A proportion of the multi-point regions have been implicated in previous studies, thereby decreasing risk of false-positive results. However neither our two-point, nor multi-point scores reached the threshold value for significance of 3. 6. Nevertheless three regions were suggestive of linkage.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Nature Publishing Group
ISSN: 1359-4184
Last Modified: 17 Nov 2022 11:57

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