No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease

Wavrant-DeVrieze, F., Rudrasingham, V., Lambert, J. C., Chakraverty, S., Kehoe, P., Crook, R., Amouyel, P., Wu, W., Holmans, Peter Alan ORCID: https://orcid.org/0000-0003-0870-9412, Rice, Frances ORCID: https://orcid.org/0000-0002-9484-1729, Perez-Tur, J., Frigard, B., Morric, J. C., Carty, S., Cottel, D., Tunstall, N., Lovestone, S., Petersen, R. C., Chartier-Harlin, M. C., Goate, A., Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Williams, Julie ORCID: https://orcid.org/0000-0002-4069-0259 and Hardy, J. 1999. No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease. Neuroscience Letters 262 (2) , pp. 137-139. 10.1016/S0304-3940(99)00035-X

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Abstract

Recent reports have suggested that variability in the alpha2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polymorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Elsevier Scientific Publishers Ireland
ISSN:	0304-3940
Last Modified:	31 Oct 2022 09:32
URI:	https://orca.cardiff.ac.uk/id/eprint/81441

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