The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease

Kehoe, P. G., Williams, H., Holmans, Peter Alan ORCID: https://orcid.org/0000-0003-0870-9412, Wilcock, G., Cairns, N. J., Neal, J. and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 1998. The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease. Journal of Medical Genetics 35 (12) , pp. 1034-1035. 10.1136/jmg.35.12.1034

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Abstract

Previous work has shown an association between the K variant of the butyrylcholinesterase (BCHE) gene and Alzheimer's disease (AD) in patients carrying the epsilon4 allele of ApoE. We attempted to replicate this finding in 181 UK white AD cases and 71 controls. No difference was found in BCHE-K genotypes (p=0.75) or alleles (p=0.70) between patients and controls. Moreover, despite a significant excess of ApoE epsilon4 in patients versus controls (p<0.0001), we found no evidence to support previous reports of an interaction between ApoE and BCHE-K (chi2=1.49, df=4, p=0.83).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	British Medical Association
ISSN:	0022-2593
Last Modified:	31 Oct 2022 09:33
URI:	https://orca.cardiff.ac.uk/id/eprint/81527

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