Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Longevity GWAS using the Drosophila Genetic Reference Panel

Ivanov, Dobril K. ORCID:, Escott-Price, Valentina ORCID:, Ziehm, Matthias, Magwire, Michael M., Mackay, Trudy F. C., Partridge, Linda and Thornton, Janet M. 2015. Longevity GWAS using the Drosophila Genetic Reference Panel. Journals of Gerontology, Series A 70 (12) , pp. 1470-1478. 10.1093/gerona/glv047

[thumbnail of glv047.pdf]
PDF - Published Version
Available under License Creative Commons Attribution.

Download (2MB) | Preview


We used 197 Drosophila melanogaster Genetic Reference Panel (DGRP) lines to perform a genome-wide association analysis for virgin female lifespan, using ~2M common single nucleotide polymorphisms (SNPs). We found considerable genetic variation in lifespan in the DGRP, with a broad-sense heritability of 0.413. There was little power to detect signals at a genome-wide level in single-SNP and gene-based analyses. Polygenic score analysis revealed that a small proportion of the variation in lifespan (~4.7%) was explicable in terms of additive effects of common SNPs (≥2% minor allele frequency). However, several of the top associated genes are involved in the processes previously shown to impact ageing (eg, carbohydrate-related metabolism, regulation of cell death, proteolysis). Other top-ranked genes are of unknown function and provide promising candidates for experimental examination. Genes in the target of rapamycin pathway (TOR; Chrb, slif, mipp2, dredd, RpS9, dm) contributed to the significant enrichment of this pathway among the top-ranked 100 genes (p = 4.79×10(-06)). Gene Ontology analysis suggested that genes involved in carbohydrate metabolism are important for lifespan; including the InterPro term DUF227, which has been previously associated with lifespan determination. This analysis suggests that our understanding of the genetic basis of natural variation in lifespan from induced mutations is incomplete.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Advanced Research Computing @ Cardiff (ARCCA)
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Publisher: Oxford University Press (OUP): Policy B - Oxford Open Option D
ISSN: 1079-5006
Date of First Compliant Deposit: 16 September 2019
Date of Acceptance: 26 March 2015
Last Modified: 05 Jan 2024 04:43

Citation Data

Cited 66 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics