Factor-derived subsyndromes of schizophrenia and familial morbid risks

Cardno, Alastair, Holmans, Peter Alan ORCID: https://orcid.org/0000-0003-0870-9412, Harvey, I., Williams, M. B., Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 and McGuffin, P. 1996. Factor-derived subsyndromes of schizophrenia and familial morbid risks. Schizophrenia Research 18 (2-3) , IVA2-IVA2.

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Abstract

Factor analysis was performed on OPCRIT checklist ratings from 66 patients with RDC schizophrenia. Eight substantive factors were found, characterised respectively by: positive formal thought disorder; first rank delusions; first rank hallucinations; inappropriate affect/bizarre behaviour; negative symptoms; grandiose/bizarre delusions; delusions of influence/persecution; and other hallucinations. A history of schizophrenia and other non-affective psychoses was ascertained in the probands' first-degree relatives using a family history approach. Illness in relatives was best predicted by probands' scores on subsyndromes derived from the inappropriate affect/bizarre behaviour and positive formal thought disorder factors.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Elsevier
ISSN:	0920-9964
Last Modified:	31 Oct 2022 09:35
URI:	https://orca.cardiff.ac.uk/id/eprint/81626

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