Mood-stabilizers: the archeology of the concept

Harris, Margaret, Chandran, Summit, Chakraborty, Nabonita and Healy, David 2003. Mood-stabilizers: the archeology of the concept. Bipolar Disorders 5 (6) , pp. 446-452. 10.1046/j.1399-5618.2003.00069.x

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Abstract

OBJECTIVE: To review the history of 'mood-stabilizing' treatments. METHOD: We have reviewed primary source data on the origin of the use of current mood-stabilizers. RESULTS: This historical record on the origins of the mood-stabilizers points to a more ambiguous picture as regards pharmacotherapeutic specificity to bipolar disorders than is commonly conceded. CONCLUSIONS: This review suggests a need for alternative formulations of the concept of a mood-stabilizer. An alternative to the currently dominant paradigm is that these agents have treatment effects, which need to be matched more precisely with patients' constitutional types in order to optimize outcomes.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Schools > Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Blackwell
ISSN:	1398-5647
Last Modified:	21 Dec 2015 14:01
URI:	https://orca.cardiff.ac.uk/id/eprint/81817

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