Thapar, Anita  ORCID: https://orcid.org/0000-0002-3689-737X and McGuffin, P.
1997.
Anxiety and depressive symptoms in childhood--a genetic study of comorbidity.
Journal of Child Psychology and Psychiatry
38
(6)
, pp. 651-656.
10.1111/j.1469-7610.1997.tb01692.x
|
Abstract
Anxiety and depressive symptoms commonly co-occur yet the underlying mechanisms for this covariation remain poorly understood. Genetic strategies are a useful means of investigating whether the comorbidity of two sets of symptoms or disorders can be explained by the same aetiological factors. In this paper we use a systematically ascertained sample of 172 twin pairs aged 8 to 16 years to examine the causes of covariation of maternally rated anxiety and depressive symptoms. The results suggest that most of the covariation can be explained by a common set of genes that influence anxiety and depressive symptoms. Some covariation between anxiety and depressive symptoms is also explained by environmental influences of the non-shared type. In addition, depressive symptoms also appear to be influenced by specific genetic factors.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII) |
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Publisher: | Wiley-Blackwell |
| ISSN: | 0021-9630 |
| Last Modified: | 22 Jul 2024 14:16 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/81836 |
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