Association between schizophrenia and a microsatellite polymorphism at the dopamine D5 receptor gene

Williams, Nigel Melville ORCID: https://orcid.org/0000-0003-1177-6931, Cardno, A. G., Murphy, K. C., Jones, L. A., Asherson, P., McGuffin, P. and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 1997. Association between schizophrenia and a microsatellite polymorphism at the dopamine D5 receptor gene. Psychiatric Genetics 7 (2) , pp. 83-85. 10.1097/00041444-199722000-00005

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Abstract

An association study of 97 patients with DSM-III-R schizophrenia and 97 matched controls was performed using a polymorphic microsatellite repeat at the dopamine D5 receptor gene. We observed a significant difference between the allele frequencies of patients and controls (chi 2 = 23.4, df = 12, p = 0.019). This reflects an excess of allele 4 (140 bp) in the patients when compared with the control sample (chi 2 = 7.087, p < 0.01; odds ratio = 2.98, 95% CI 1.29-6.86). However, this association remains tentative until confirmation in other samples.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Lippincott Williams & Wilkins
ISSN:	0955-8829
Last Modified:	17 Jul 2023 06:49
URI:	https://orca.cardiff.ac.uk/id/eprint/81853

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