Linkage study of chromosome 6p in sib-pairs with schizophrenia

Daniels, J. K., Spurlock, G., Williams, Nigel Melville ORCID: https://orcid.org/0000-0003-1177-6931, Cardno, A. G., Jones, L. A., Murphy, K. C., Asherson, P., Holmans, Peter Alan ORCID: https://orcid.org/0000-0003-0870-9412, Fenton, I., McGuffin, P. and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 1997. Linkage study of chromosome 6p in sib-pairs with schizophrenia. American Journal of Medical Genetics 74 (3) , pp. 319-323. 10.1002/(SICI)1096-8628(19970531)74:3<319::AID-AJMG14>3.0.CO;2-R

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Abstract

Following reports of linkage between schizophrenia and markers in the chromosomal region 6p24-22 we have studied nine microsatellite markers spanning 40 cM of this region in our sample of 102 affected sibling pairs from 86 families. Allele sharing identity by descent was examined using likelihood based sib-pair analysis as implemented by the program SPLINK. No evidence for linkage was obtained and the highest lod score was only 0.192 for D6S309. We conclude that if there is a susceptibility locus for schizophrenia in this region then its effect size is so small as to render our study insufficiently powerful to detect it.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Wiley
ISSN:	0148-7299
Last Modified:	17 Nov 2022 12:24
URI:	https://orca.cardiff.ac.uk/id/eprint/81864

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