Association between a PS-1 intronic polymorphism and late onset Alzheimer's disease

Kehoe, P., Williams, Julie ORCID: https://orcid.org/0000-0002-4069-0259, Holmans, Peter Alan ORCID: https://orcid.org/0000-0003-0870-9412, Liddell, M., Lovestone, S., Holmes, C., Powell, J., Neal, J., Wilcock, G. and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 1996. Association between a PS-1 intronic polymorphism and late onset Alzheimer's disease. NeuroReport 7 (13) , pp. 2155-2158. 10.1097/00001756-199609020-00019

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Abstract

Previous work suggests an association between allele 1 and the 1-1 genotype of an intronic polymorphism in the presenilin-1 (PS-1) gene and late onset Alzheimer's disease. We found an excess of the 1-1 genotype in our late onset clinical sample (p = 0.006, one-tailed) but not in our postmortem confirmed sample, which instead exhibited an excess of allele 1 (p = 0.02, one-tailed). No interaction between PS-1 and ApoE genotype was detected and the findings remained significant when the effects of ApoE were taken into account (p = 0.03, one-tailed). These results suggest that the PS-1 polymorphism, or a locus in linkage disequilibrium with it, acts as a risk factor for late onset AD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Lippincott, Williams & Wilkins
ISSN:	0959-4965
Last Modified:	31 Oct 2022 09:40
URI:	https://orca.cardiff.ac.uk/id/eprint/82030

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