No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.

Payton, A., Turic, D., Langley, Kate ORCID: https://orcid.org/0000-0002-2033-2657, Mills, S., Lawson, D.C., van den Bree, Marianne Bernadette ORCID: https://orcid.org/0000-0002-4426-3254, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379, Ollier, W., Worthington, J. and Thapar, Anita ORCID: https://orcid.org/0000-0002-3689-737X 2003. No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder. Psychiatric Genetics 13 (3) , pp. 183-185.

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Abstract

OBJECTIVES: There has been a recent resurgence in interest in the role of autoimmunity in childhood neuropsychiatric disorders. Significant association between HLA-DRB1 and attention deficit hyperactivity disorder (ADHD) in a case-control study of 31 subjects has been reported but there have been no other published studies following up these results. We attempted to replicate these findings. METHODS: In a well-characterized sample of 173 children with ADHD, using a fully automated sequence-specific oligonucleotide method for HLA genotyping, association between ADHD and HLA-DRB1 was tested for using the Transmission Disequilibrium Test and case-control analysis. RESULTS: Transmission Disequilibrium Test analysis yielded a chi-square of 10.694 with a simulated global P value of 0.1641 for the full sample, and a chi-square value of 11.307 with a simulated global P value of 0.1323 for the complete trios only. CONCLUSION: There was no evidence of association of HLA-DRB1 and ADHD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Schools > Medicine Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Lippincott Williams & Wilkins
ISSN:	0955-8829
Last Modified:	17 Nov 2022 12:33
URI:	https://orca.cardiff.ac.uk/id/eprint/82068

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