Medication effects in neuroimaging studies of bipolar disorder

Phillips, Mary L., Travis, Michael J., Fagiolini, Andrea and Kupfer, David J. 2008. Medication effects in neuroimaging studies of bipolar disorder. American Journal of Psychiatry 165 (3) , pp. 313-320. 10.1176/appi.ajp.2007.07071066

Full text not available from this repository.

Abstract

OBJECTIVE: Neuroimaging studies are promising components for a new diagnostic framework for bipolar disorder, but a major issue is the potential confound of psychotropic medication upon experimental measures. Withdrawing all individuals from medication and examining only unmedicated individuals may be clinically unfeasible, and examining only unmedicated individuals may render findings less generalizable. METHOD: The authors review structural and functional neuroimaging studies of medicated and unmedicated patients with bipolar disorder to discern the possible confounding effect of medication. RESULTS: Findings from studies identified on MEDLINE that included medicated individuals with bipolar disorder indicated either no significant effect or ameliorative effects of psychotropic medications on abnormal structural and functional neuroimaging measures relevant to pathophysiologic mechanisms of the disorder. Different strategies for assessing medication effects are compared. CONCLUSIONS: Neuroimaging studies of bipolar disorder ideally should recruit both unmedicated and medicated individuals. Individuals who are unable to tolerate medication withdrawal likely have more severe illness and are especially informative for research examining biomarkers of illness and treatment response.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	American Psychiatric Association
ISSN:	0002-953X
Last Modified:	25 Nov 2015 13:58
URI:	https://orca.cardiff.ac.uk/id/eprint/82320

Citation Data

Cited 275 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item