Neural correlates of deficient response inhibition in mentally disordered violent individuals

Barkataki, Ian, Kumari, Veena, Das, Mrigen, Sumich, Alex, Taylor, Pamela Jane ORCID: https://orcid.org/0000-0002-3998-6095 and Sharma, Tonmoy 2008. Neural correlates of deficient response inhibition in mentally disordered violent individuals. Behavioral Sciences & the Law 26 (1) , pp. 51-64. 10.1002/bsl.787

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Abstract

In this study, response inhibition and associated neural activation during a motor inhibition paradigm were investigated in (i) men with antisocial personality disorder (APD) with a history of violence (n = 14), (ii) men with schizophrenia with a history of violence (n = 12), (iii) men with schizophrenia without a history of violence (n = 12), and (iv) healthy control subjects (n = 14) using functional magnetic resonance imaging (fMRI). At the behavioural level, individuals with schizophrenia showed impaired performance across all conditions, whereas an increased error rate was seen in the APD group only during the conditions requiring inhibition. At the neural level, both violent groups showed reduced thalamic activity, compared with controls, in association with modulation of inhibition by task demands. In addition, the violent schizophrenia group, compared with controls, showed reduced activity in the caudate nucleus during the condition requiring inhibition. It is concluded that violence may not be specifically associated with impaired voluntary inhibition in schizophrenia but this is likely in APD. Reduced thalamic function, perhaps due to its known association with sensorimotor disturbances, is implicated in violent behaviour across both disorders. In addition, caudate dysfunction may contribute, given its role in timing and temporal processing as well as suppression of motor actions, to deficient inhibition and violent behaviour in schizophrenia.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	John Wiley & Sons Ltd.
ISSN:	0735-3936
Last Modified:	31 Oct 2022 09:45
URI:	https://orca.cardiff.ac.uk/id/eprint/82340

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