IQ and variation in the number of fragile X CGG repeats: No association in a normal sample

Daniels, J.K., Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, McGuffin, Peter, Thompson, Lee, Detterman, Douglas K., Chorney, Michael, Chorney, Karen, Smith, Deborah, Skuder, Patricia, Vignetti, Sylvia, McClearn, Gerald E. and Plomin, Robert 1994. IQ and variation in the number of fragile X CGG repeats: No association in a normal sample. Intelligence 19 (1) , pp. 45-50. 10.1016/0160-2896(94)90052-3

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Abstract

Fragile X mental retardation is associated with an unstable expansion of a CGG repeat in the FMR-1 gene on the X chromosome (Xq27.3). We asked whether variation in the number of FMR-1 CGG repeats relates to IQ in the general population. FMR-1 CGG repeats were genotyped for three groups: low IQ (mean IQ = 71, N = 35), middle IQ (mean IQ = 103, N = 19), and high IQ (mean IQ = 137, N = 49). The IQ groups did not differ significantly in number of FMR-1 CGG repeats for males or females.

Item Type:	Article
Status:	Published
Schools:	Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII)
Subjects:	R Medicine > R Medicine (General)
ISSN:	01602896
Last Modified:	31 Oct 2022 09:46
URI:	https://orca.cardiff.ac.uk/id/eprint/82380

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