Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease

Hamilton, Gillian, Samedi, Farzana, Knight, Jo, Archer, Nicola, Foy, Catherine, Walter, Sarah, Turic, Dragana, Jehu, Luke, Moore, Pamela, Hollingworth, Paul, O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379, Williams, Julie ORCID: https://orcid.org/0000-0002-4069-0259, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Lovestone, Simon and Powell, John F. 2006. Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease. Neuroscience Letters 401 (1-2) , pp. 77-80. 10.1016/j.neulet.2006.03.021

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Abstract

The varepsilon4 allele of the APOE locus is the only confirmed risk factor for late-onset Alzheimer's disease (LOAD). The phosphate and tensin homolog (PTEN) gene is both a biological and positional candidate gene for LOAD. Eight polymorphisms spanning this gene were selected from dbSNP and genotyped in pooled DNA samples of both cases and controls. No evidence for association with LOAD was obtained in this study although further investigation revealed low levels of linkage disequlibrium (LD) between the genotyped SNPs. Our results suggest that it is unlikely that genetic variation within the PTEN gene contributes to risk of LOAD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
ISSN:	0304-3940
Last Modified:	31 Oct 2022 09:49
URI:	https://orca.cardiff.ac.uk/id/eprint/82548

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