Effect of ApoE and tau on age of onset of progressive supranuclear palsy and multiple system atrophy

Morris, Huw R., Schrag, Annete, Nath, Uma, Burn, David, Quinn, Niall P., Daniel, Susan, Wood, Nicholas W. and Lees, Andrew J. 2001. Effect of ApoE and tau on age of onset of progressive supranuclear palsy and multiple system atrophy. Neuroscience Letters 312 (2) , pp. 118-120. 10.1016/S0304-3940(01)02190-5

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Abstract

In addition to allelic association between genetic polymorphisms and diseases, modulation of age of onset is a well recognised effect of disease susceptibility genes. The ApoE epsilon4 allele is associated with an earlier age of onset of sporadic and familial Alzheimer's disease. It has been suggested that the tau genotype influences the age of onset of progressive supranuclear palsy (PSP), a form of atypical parkinsonism caused by tau neurofibrillary tangle deposition. We have therefore analysed the relationship between tau and ApoE genotypes and the age of onset of PSP and another form of atypical parkinsonism, multiple system atrophy (MSA). We have not found any effect of possession of the tau H1 haplotype or the ApoE epsilon4 allele on the age of onset of MSA or PSP.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Elsevier
ISSN:	0304-3940
Last Modified:	10 Jan 2018 08:09
URI:	https://orca.cardiff.ac.uk/id/eprint/82689

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