Cortical OFF-potentials from the S-cone pathway reveal neural damage in early glaucoma

H. Aldebasi, Yousef, Drasdo, Neville, Morgan, James Edwards ORCID: https://orcid.org/0000-0002-8920-1065 and V. North, Rachel 2003. Cortical OFF-potentials from the S-cone pathway reveal neural damage in early glaucoma. Vision Research 43 (2) , pp. 221-226. 10.1016/S0042-6989(02)00435-2

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Abstract

We used background adaptation and silent substitution techniques to record full-field ON and OFF-visually evoked cortical potentials (VECPs) selectively from the S-cone and L- and M-cone pathways in 15 patients with primary open angle glaucoma (POAG), and 15 normal controls. The most statistically significant (P=0.01) VECP test for POAG was a voltage change in the S-cone pathway cortical OFF-response. A sensitivity of 93% was achieved, with 60% specificity at minimum error rate. This is presumed to reflect reduced activity in the S-cone and magnocellular visual pathways, and may provide an effective method for research and monitoring change in early glaucoma.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Elsevier
ISSN:	0042-6989
Last Modified:	31 Oct 2022 09:53
URI:	https://orca.cardiff.ac.uk/id/eprint/82815

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