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Rheumatoid arthritis association at 6q23

Thomson, Wendy, Barton, Anne, Ke, Xiayi, Eyre, Steve, Hinks, Anne, Bowes, John, Donn, Rachelle, Symmons, Deborah, Hider, Samantha, Bruce, Ian N, Wilson, Anthony G, Marinou, Ioanna, Morgan, Ann, Emery, Paul, Carter, Angela, Steer, Sophia, Hocking, Lynne, Reid, David M, Wordsworth, Paul, Harrison, Pille, Strachan, David, Worthington, Jane, Fraser, Christine, Green, Elaine K., Grozeva, Detelina, Hamshere, Marian Lindsay ORCID:, Holmans, Peter Alan ORCID:, Jones, Ian Richard ORCID:, Kirov, George ORCID:, Escott-Price, Valentina ORCID:, Nikolov, Ivan, O'Donovan, Michael Conlon ORCID:, Owen, Michael John ORCID: and Craddock, Nicholas John ORCID: 2007. Rheumatoid arthritis association at 6q23. Nature Genetics 39 (12) , pp. 1431-1433. 10.1038/ng.2007.32

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The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5) - 5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3).

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Additional Information: Christine Fraser, Elaine Green, Detelina Grozeva, Marian Hamshere, Peter Holmans, Ian Jones, George Kirov, Valentina Moskvina, Ivan Nikolov, Michael O'Donovan, Michael Owen and Nick Craddock are collaborators on this article.
Publisher: Nature Publishing Group
ISSN: 1061-4036
Last Modified: 17 Nov 2022 13:05

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