Complement factor H Y402H polymorphism is not associated with late-onset Alzheimer's disease

Hamilton, Gillian, Proitsi, Petra, Williams, Julie ORCID: https://orcid.org/0000-0002-4069-0259, O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Powell, John and Lovestone, Simon 2007. Complement factor H Y402H polymorphism is not associated with late-onset Alzheimer's disease. Neuromolecular Medicine 9 (4) , pp. 331-334. 10.1007/s12017-007-8013-y

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Abstract

There is evidence to suggest a role for immune dysfunction in the pathogenesis of Alzheimer's disease, and it has previously been shown that blood plasma levels of the protein complement factor H, a member of the alternative complement pathway, was specifically elevated in people with late-onset Alzheimer's disease. We have genotyped the common complement factor H Y402H polymorphism in a large case-control cohort to investigate association with late-onset Alzheimer's disease susceptibility and find no evidence that this SNP is associated with disease risk. However, it remains possible that another variant in this gene may modify susceptibility for late-onset Alzheimer's disease.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Springer Verlag
ISSN:	1535-1084
Last Modified:	31 Oct 2022 09:56
URI:	https://orca.cardiff.ac.uk/id/eprint/82977

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