Analysis of tau haplotypes in Pick's disease

Morris, Huw. R., Baker, M., Yasojima, K., Houlden, H., Khan, M. N., Wood, N. W., Hardy, J., Grossman, M., Trojanowski, J., Revesz, T., Bigio, E. H., Bergeron, C., Janssen, J. C., McGeer, P. L., Rossor, M. N., Lees, A. J., Lantos, P. L. and Hutton, M. 2002. Analysis of tau haplotypes in Pick's disease. Neurology 59 (3) , pp. 443-445. 10.1212/WNL.59.3.443

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Abstract

Pick's disease (PiD) is characterized by the deposition of tau protein as three-repeat tau Pick bodies, whereas progressive supranuclear palsy (PSP) involves the deposition of four-repeat tau neurofibrillary tangles. PSP is associated with the tau H1 haplotype. The authors investigated a possible association between PiD and the tau H1 or H2 haplotype. There was no difference between the tau H2 haplotype or H2H2 genotype frequency in PiD cases and control subjects. No tau mutations were identified in pathologically typical cases of PiD, with antibody 12-E8-negative Pick bodies.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	American Academy of Neurology (AAN)
ISSN:	0028-3878
Last Modified:	10 Jan 2018 08:07
URI:	https://orca.cardiff.ac.uk/id/eprint/82985

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