NPY mediates basal and seizure-induced proliferation in the subcallosal zone

Laskowski, Alexandra, Howell, Owain W., Sosuov, Alexander A., McKhann, Guy and Gray, William Peter 2007. NPY mediates basal and seizure-induced proliferation in the subcallosal zone. NeuroReport 18 (10) , pp. 1005-1008. 10.1097/WNR.0b013e32815277ab

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Abstract

Stem cell niches exist around the lateral ventricle and in the subgranular layer of the dentate gyrus, supporting adult neurogenesis. Recently, a third germinal layer, the subcallosal zone has been identified supporting the generation of oligodendrocytes in the adult brain. We have previously described a proliferative role for neuropeptide Y on precursors in the dentate gyrus, caudal subventricular zone and subcallosal zone under basal conditions and in the dentate gyrus after seizures. Here we sought to determine a role for neuropeptide Y in seizure-induced proliferation in the subcallosal niche. Using the chemoconvulsant kainate and neuropeptide Y(-/-) mice with controls, we show an effect of neuropeptide Y on basal proliferation and demonstrate a significant reduction in seizure-induced proliferation in the subcallosal zone.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Lippincott, Williams & Wilkins
ISSN:	0959-4965
Last Modified:	13 Sep 2024 01:12
URI:	https://orca.cardiff.ac.uk/id/eprint/83036

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