Zammit, Stanley  ORCID: https://orcid.org/0000-0002-2647-9211, Lewis, G., Thapar, Anita ORCID: https://orcid.org/0000-0002-3689-737X, Owen, R., Jones, G., Jones, S., Sanders, R., Milham, C., Mahdi, A., O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862
2006.
Phenotypic variation between parent-offspring trios and non-trios in genetic studies of schizophrenia.
Journal of Psychiatric Research
40
(7)
, pp. 622-626.
10.1016/j.jpsychires.2005.05.006
|
Abstract
BACKGROUND: Phenotypic differences between parent-offspring trios and non-trios have been reported for various psychiatric disorders, and it has been suggested that this may make comparisons of case-control and family-based results for gene-disease association studies inappropriate. AIMS: To compare phenotypes between trios and non-trios with schizophrenia, and explore possible reasons for differences observed. METHOD: Phenotypes were compared between trios (n=75) and non-trios (n=424) collected as part of a case-control study. RESULTS: Differences were observed for most phenotypes investigated, although all were eliminated after adjusting for confounding. CONCLUSIONS: Confounding, genetic heterogeneity or selection bias could result in differences in case-control and family-based results. However as we discuss, where adequately designed case-control studies are used, gene-disease association results would be incomparable between family-based and case-control studies only if genetic heterogeneity was present. These results do not support the presence of such genetic heterogeneity in schizophrenia.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII) |
| Subjects: | R Medicine > R Medicine (General) |
| Publisher: | Elsevier |
| ISSN: | 0022-3956 |
| Last Modified: | 17 Nov 2022 13:27 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/83428 |
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